Rapid formation of carcinogenic N-nitrosamines in aqueous alkaline solutions
نویسندگان
چکیده
منابع مشابه
Photoionization of Indole in Alkaline Aqueous Solutions
The photoionization process of indole in alkaline aqueous solutions at 77 °K and the recombination process of trapped electron with its mother molecule were investigated. The fluorescence spectrum of indole in these glassy media depended on the NaOH concentration; the disappearance of the 325 nm band at the NaOH concentrations higher than 5 M with the appearance of a fluorescence band at 375 nm...
متن کاملFormation and Metabolism of N-Nitrosamines
The formation of nitrosamines and reactions of the first and second phase of their biotransformations were reviewed.
متن کاملCarcinogenic tobacco-specific N-nitrosamines in snuff and in the saliva of snuff dippers.
Human data indicate an increased risk for cancer of the oral cavity for snuff dippers. Popular snuff products from the United States, Germany, Sweden, and Denmark were analyzed for tobacco-specific N-nitrosamines (TSNA). These compounds are formed during tobacco processing from nicotine, nornicotine, and anatabine and represent the only known carcinogens in snuff. N'-Nitrosonornicotine, a moder...
متن کاملComparison of cytochrome P-450- and peroxidase-mediated activations of carcinogenic azo dyes and N-nitrosamines.
Carcinogenic azo dyes (dimethylaminoazobenzene, Sudan I) and N-nitrosamines (N-nitrosomethylaniline, N-nitrosomethylbenzylamine) are oxidized by cytochrome P-450 isoenzymes and peroxidase yielding metabolites which in vitro bind to DNA and transfer RNA (tRNA). The parallelism and differences in oxidative reactions are described. Peroxidase is more effective than P-450 in activating reactions of...
متن کاملMercury(II) penicillamine complex formation in alkaline aqueous solution.
The complex formation between mercury(II) and penicillamine (H(2)Pen = 3,3'-dimethyl cysteine) in alkaline aqueous solutions (pH approximately 2) has been investigated with extended X-ray absorption fine structure (EXAFS) and 199Hg NMR spectroscopy. By varying the penicillamine concentration (C(H(2)Pen) = 0.2-1.25 M) in approximately 0.1 M Hg(II) solutions, two coexisting major species [Hg(Pen)...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1977
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1977.106